Cornwell's book (left) topped The Sunday Times bestseller list
The winning advert, which will be chosen by Cornwell herself, will be broadcast on Five to tie-in with the launch of the paperback in April.
Fans of all ages are being asked to submit either a 20-second short film, a script or storyboard.
Six applicants will be selected and the winner will be announced on 17 March.
Book Of The Dead stayed at number one in The Sunday Times bestseller list for eight weeks following the hardback's publication.